This is Why I Play Boggle in the Middle of the Night Instead of Reading about My Various Medical Problems

Tell me if you don't think BOGGLE sounds like more fun than this.

And the Bogglers are funny and friendly and everybody cheers everybody on.

It's a healthy sporting environment.

Festive. Sportive.

And you learn new words.

Or invent them.

Same difference.

Plus, you win badges.

That doesn't do anything for me but Lee likes it.

Lee has ten bazillion eight hundred and eighty-eight thousand three hundred and fifty-thirteen badges.

Something like that.

The badge today was stupid and way too easy to get.

I must admit, the "Holy Molar" badge last week was cute.

Yes, it's a tooth character.

I do like some of the animated badges.

And Lee does have some cute ocean animated ones.



I guess pretty soon I'll have to figure out a way to get bled.

I don't think it's necessary to do it in a medical setting.

I'll just buy some pet leeches.

And let them feed on me.

And YouTube it.

That should get some hits.

People like cringing.



Thank you for the depressing "correlation" you told me about here, INGENTA.

Now go make a viable and assimilatable form of IvIgM, okay?

You make intravenous immunoglobulin that works for G deficient people, what about us SIgM-D'ers?



Don't get a rare disease because rare means not many people will be very concerned about fixing it.

Since not very many people have it.

I suspect a lot of people do have it, they just don't know.

Why they're sick all the time.



Better yet, don't get two or more statistically rare diseases.



BOGGLE nonstop to avoid thinking about these things.

That's my recent strategy.



I did notice a slight improvement in my health lately.


But I think that's because I'm getting too confused to remember to be anxious as often anymore.


Today I did it again. I almost wrote a check for something I wrote a check for several days ago. Thank goodness I called PPL and they verified they got it.

Because here I had taken out the checkbook.


It has something to do with new memory formation.

I don't think I have Alzheimer's at all.


But this could be a side effect of the hemochromoatosis.

The iron builds up in many organs.

I think my kidneys are feeling it.


I gave up drinking long ago and the tests came back okay on them.

But there are problems. I can tell. I know my left kidney is gonna betray me. I feel it sometimes.

It's a bad penny.


I guess you can go on one.


The thing is I'm wondering if the iron is building up in the brain too.

I'm like those crazy Romans drinking out of lead pots and losing their minds and not knowing why.

I limit it in my diet and make sure it's not in my vitamins, etc.

But it gets in. And it doesn't get out.

That's the disease.

Toxicity.

I need bled.

The doc wrote a bunch of tests I have no money for so the orders sit unfilled.

Transferrin tests and about five others.



I spend most of my time with psychologists/psychiatrists talking about hematology/genetics/immunoglobulin deficiencies.

And then they write "crazy crazy crazy" on the clipboard.

Because what do they know about any of those things.

Even if some of them are M.D.s

They don't think about things like that because that's not what they get paid to think about.

They want to give you more meds.

And I can't take most of the things they want to put in my body.

"My body has strange information" as Suzanne Vega sings.

It doesn't need more metals. In those bipolar medicines or anything else. Even the herbs and spices I love so much. Toxic toxic toxic.

Drink water.

Eat pulse.

Be like Daniel.

Sleep in the lion's den.

Sing in the furnace.

BOGGLE!

Or as Peggy Hill calls it, "The Boggle."

I love that.

"The cancer."

"The AIDS."

The gays."

But not "The death" oddly enough.

Why do old people talk like that?





Abstract:

Summary

Low CD8+ T lymphocyte numbers have long been described in hereditary haemochromatosis (HH). Recently, two conserved haplotypes localized near the microsatellite D6S105 at the major histocompatibility complex (MHC) class I region were described predicting the clinical expression of HH and the CD8+ T lymphocyte numbers. The A-A-T haplotype was associated with a severe clinical expression of HH and low CD8+ T lymphocyte numbers, while the G-G-G haplotype was associated with a milder clinical expression of HH and high CD8+ T lymphocyte numbers. As CD8+ T lymphocytes are a very heterogeneous population, in this study we analysed the CD8+ subpopulations of naive, central memory (TCM) and effector memory (TEM), and further subsets of CD8+ TEM cells in 47 HH patients and 68 controls. In addition, association studies were conducted between the conserved haplotypes and the CD8+ T cell subpopulations in HH. Variations of the numbers of naive and central memory cells with age were similar between HH patients and controls. For TEM cells and the TEM CD27-CD28- subset no effect of age was observed in HH [R2 = 0·001, not significant (n.s.) and R2 = 0·01, n.s., respectively] contrasting with the increasing of these subpopulations with age in controls (R2 = 0·09, P = 0·017 and R2 = 0·22, P = 0·0005, respectively). Interestingly, patients homozygous for the A-A-T haplotype have lower numbers of CD8+ TEM cells due especially to lower numbers of TEM CD27-CD28- (0·206 ± 0·119 and 0·066 ± 0·067 × 106 cells/ml, respectively) than patients carrying the G-G-G haplotype (0·358 ± 0·195 and 0·246 ± 0·202 × 106 cells/ml, respectively). This may suggest an inability of HH patients to differentiate the CD8+ T cells into the most mature phenotype